- CAS7752-82-1
- Purity99%
Location：Home > Pharmaceutical> 2-Amino-5-bromopyrimidine
Buy cost-effective 99% pure 2-Amino-5-bromopyrimidine 7752-82-1 now
- Molecular Formula:C4H4BrN3
- Molecular Weight:174
- Appearance/Colour:yellow solid
- Vapor Pressure:0mmHg at 25°C
- Melting Point:241-243 °C(lit.)
- Refractive Index:1.649
- Boiling Point:340.743 °C at 760 mmHg
- PKA:1.93±0.10(Predicted)
- Flash Point:159.876 °C
- PSA：51.80000
- Density:1.844 g/cm3
- LogP:1.40250
2-Amino-5-bromopyrimidine(Cas 7752-82-1) Usage
|
Synthesis |
The synthesis of 2-Amino-5-bromopyrimidine is as follows:The 2-aminopyrimidine (2.5g, 26.29mmol) was dissolved in acetonitrile (25mL) was added N- bromosuccinimide (4.6g, 27.9mmol) under ice-cooling, stirred in the dark overnight at room temperature. Recovery of the solvent under reduced pressure, washed with water (100 mL) was washed, filtered off with suction, and dried in vacuo to give a white solid. Yield: 97%. |
|
storage |
Store in cool, well ventilated area. Keep container tightly closed. Light sensitive. Store under argon. |
|
General Description |
Crystal structure of 2-amino-5-bromopyrimidine was studied. |
InChI:InChI=1/C4H4BrN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)
7752-82-1 Relevant articles
Introducing a potential lead structure for the synthesis of more specific inhibitors of tyrosinases and catechol oxidases
Amirzakaria, Javad Zamani,Eshghi, Hossein,Ghorbanian, Nargess,Haghbeen, Faheimeh,Haghbeen, Kamahldin,Hajatpour, Golnaz
, (2021/09/22)
Based on tyrosinase inhibition science, ...
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
Tong, Lexian,Song, Pinrao,Jiang, Kailong,Xu, Lei,Jin, Tingting,Wang, Peipei,Hu, Xiaobei,Fang, Sui,Gao, Anhui,Zhou, Yubo,Liu, Tao,Li, Jia,Hu, Yongzhou
, p. 44 - 62 (2019/04/17)
Through virtual screening, we identified...
Proton Sensitive Functional Organic Fluorescent Dyes Based on Coumarin-imidazo[1,2-a]pyrimidine; Syntheses, Photophysical Properties, and Investigation of Protonation Ability
Ayd?ner, Burcu,Sefero?lu, Zeynel
, p. 5921 - 5934 (2018/11/23)
A novel series of 2-coumarin-3-yl-imidaz...
2-polysubstituted aromatic ring-pyrimidine derivative and preparation and medical application
-
Paragraph 0210; 0214; 0215; 0216, (2017/05/20)
The invention provides a 2-polysubstitut...
7752-82-1 Process route
-
-
109-12-6
2-aminopyrimidine
-
-
7752-82-1
5-bromo-2-aminopyrimidine
Conditions
| Conditions | Yield |
|---|---|
|
With
N-Bromosuccinimide; ammonium acetate;
In
acetonitrile;
at 20 ℃;
for 0.0833333h;
|
100% |
|
With
N-Bromosuccinimide; ammonium acetate;
In
acetonitrile;
at 20 ℃;
for 0.5h;
|
98% |
|
With
N-Bromosuccinimide;
In
acetonitrile;
at 20 ℃;
Cooling with ice;
Darkness;
|
97% |
|
With
1-butyl-3-methylimidazolium tribromide;
at -10 ℃;
for 0.0833333h;
|
96% |
|
With
N-Bromosuccinimide;
In
acetonitrile;
Inert atmosphere;
Reflux;
|
94% |
|
With
N-Bromosuccinimide;
In
dichloromethane; acetonitrile;
at 5 - 20 ℃;
for 24h;
|
92.4% |
|
With
N-Bromosuccinimide;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 72h;
|
91% |
|
With
N-Bromosuccinimide;
In
methanol; acetonitrile;
at 70 ℃;
for 6h;
Temperature;
Solvent;
|
90.48% |
|
With
N-Bromosuccinimide;
In
acetonitrile;
at 20 ℃;
for 4h;
|
90.2% |
|
2-aminopyrimidine;
With
n-butyllithium;
In
diethyl ether;
at -78 - 20 ℃;
With
trimethyltin(IV)chloride;
In
diethyl ether;
at -78 ℃;
for 24h;
With
bromine;
In
diethyl ether;
at -78 - 20 ℃;
for 2h;
Further stages.;
|
88% |
|
With
N-chloro-N-fluoro-benzenesulfonamide; potassium bromide;
In
acetonitrile;
at 20 ℃;
for 0.25h;
|
88% |
|
With
N-Bromosuccinimide; ammonium acetate;
In
acetonitrile;
at 20 ℃;
Darkness;
|
87% |
|
With
N-Bromosuccinimide;
In
acetonitrile;
Cooling with ice;
Darkness;
Reflux;
|
85% |
|
With
bromine; sodium hydrogencarbonate;
In
acetic acid;
1.) 2 h, 2.) 1 h;
|
75% |
|
With
n-butyllithium; Trimethyl borate; bromine;
In
tetrahydrofuran;
at -78 - 0 ℃;
|
70% |
|
With
3-bromo-6-chloroimidazo<1,2-b>pyridazine hydrobromide-bromine;
for 1.5h;
Ambient temperature;
|
44% |
|
With
bromine;
In
water;
at 20 ℃;
for 2h;
|
42% |
|
With
water; bromine;
|
|
|
With
water; bromine; calcium carbonate;
|
|
|
With
N-Bromosuccinimide;
In
acetonitrile;
Reflux;
|
-
-
504-29-0
2-aminopyridine
-
-
7752-82-1
5-bromo-2-aminopyrimidine
Conditions
| Conditions | Yield |
|---|---|
|
With
N-Bromosuccinimide;
In
acetonitrile;
at 20 ℃;
Darkness;
Cooling with ice;
|
97% |
7752-82-1 Upstream products
-
109-12-6
2-aminopyrimidine
-
35034-15-2
2‐aminopyrimidine‐1‐oxide
-
7664-41-7
ammonia
-
32779-36-5
5-Bromo-2-chloropyrimidine
7752-82-1 Downstream products
-
38373-55-6
benzyl-(5-bromo-pyrimidin-2-yl)-amine
-
91348-67-3
N-(5-bromopyrimidin-2-yl)-4-methylbenzenesulfonamide
-
860515-93-1
3-nitro-benzenesulfonic acid-(5-bromo-pyrimidin-2-ylamide)
-
132635-73-5
N-(5-Bromo-pyrimidin-2-yl)-2-methyl-benzamidine