- CAS147817-50-3
- Purity99%
Location：Home > Others> SIRAMESINE
Reliable factory customized supply SIRAMESINE 147817-50-3
- Molecular Formula:C30H31 F N2 O
- Molecular Weight:454.587
- Boiling Point:611.4±55.0 °C(Predicted)
- PKA:9.45±0.20(Predicted)
- PSA：17.40000
- Density:1.19±0.1 g/cm3(Predicted)
- LogP:6.55170
147817-50-3 Relevant articles
Novel indole-based sigma-2 receptor ligands: synthesis, structure-affinity relationship and antiproliferative activity
Xie, Fang,Kniess, Torsten,Neuber, Christin,Deuther-Conrad, Winnie,Mamat, Constantin,Lieberman, Brian P.,Liu, Boli,Mach, Robert H.,Brust, Peter,Steinbach, J?rg,Pietzsch, Jens,Jia, Hongmei
supporting information, p. 1093 - 1103 (2015/06/25)
We report the synthesis and biological e...
N-Arylation of indoles with 4-[18F]fluoroiodobenzene: Synthesis of 18F-labelled σ2 receptor ligands for positron emission tomography (PET)
Wuest, Frank R.,Kniess, Torsten
, p. 31 - 43 (2007/10/03)
The palladium-mediated N-arylation of in...
1'-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine] hydrohalogenides
-
, (2008/06/13)
The present invention relates to a hydro...
Piperidine derivatives having anxiolytic effect
-
, (2008/06/13)
Piperidine compounds having the general ...
147817-50-3 Process route
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3364-37-2
4-(1H-indol-3-yl)butan-1-ol
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147817-50-3
siramesine
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: 44 percent / CuI; ZnO; K2CO3 / 1-methyl-pyrrolidin-2-one / 160 °C
2: triethylamine / CH2Cl2 / 0 - 20 °C
3: Na2CO3 / H2O; acetone / 50 °C
With
copper(l) iodide; sodium carbonate; potassium carbonate; triethylamine; zinc(II) oxide;
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; acetone;
1: Ullmann arylation reaction;
|
|
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Multi-step reaction with 3 steps
1: 58 percent / K2CO3, CuI, ZnO, 1-methyl-2-pyrrolidinone / 6 h / 155 °C
2: 95 percent / triethylamine / CH2Cl2 / 1.5 h / 10 - 20 °C
3: K2CO3, methyl isobutyl ketone / 16 h / Heating
With
1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate; triethylamine; 4-methyl-2-pentanone; zinc(II) oxide;
In
dichloromethane;
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133-32-4
4-indol-3-yl-butyric acid
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147817-50-3
siramesine
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1: LiAlH4 / tetrahydrofuran / 4 h / 20 °C
2: 44 percent / CuI; ZnO; K2CO3 / 1-methyl-pyrrolidin-2-one / 160 °C
3: triethylamine / CH2Cl2 / 0 - 20 °C
4: Na2CO3 / H2O; acetone / 50 °C
With
copper(l) iodide; lithium aluminium tetrahydride; sodium carbonate; potassium carbonate; triethylamine; zinc(II) oxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetone;
2: Ullmann arylation reaction;
|
|
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Multi-step reaction with 5 steps
1: 96 percent / HCl (gas) / 1.5 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 0.67 h
3: 58 percent / K2CO3, CuI, ZnO, 1-methyl-2-pyrrolidinone / 6 h / 155 °C
4: 95 percent / triethylamine / CH2Cl2 / 1.5 h / 10 - 20 °C
5: K2CO3, methyl isobutyl ketone / 16 h / Heating
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; 4-methyl-2-pentanone; zinc(II) oxide;
In
tetrahydrofuran; dichloromethane;
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147817-50-3 Upstream products
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38309-60-3
3H-spiro[2-benzofuran-1,4'-piperidine]
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163630-97-5
4-<1-(4-fluorophenyl)-1H-indol-3-yl>-1-butanol methanesulfonate ester
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3364-37-2
4-(1H-indol-3-yl)butan-1-ol
-
133-32-4
4-indol-3-yl-butyric acid